Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M2

Ligand

BDBM50077548

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_140047 (CHEMBL745864)

IC50

10±n/a nM

Citation

Jeppesen, L; Olesen, PH; Hansen, L; Sheardown, MJ; Thomsen, C; Rasmussen, T; Jensen, AF; Christensen, MS; Rimvall, K; Ward, JS; Whitesitt, C; Calligaro, DO; Bymaster, FP; Delapp, NW; Felder, CC; Shannon, HE; Sauerberg, P 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives. J Med Chem42:1999-2006 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M2

Name:

Muscarinic acetylcholine receptor M2

Synonyms:

ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51555.53

Organism:

RAT

Description:

P10980

Residue:

466

Sequence:

MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

BDBM50077548

n/a

Name

BDBM50077548

Synonyms:

1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]thiadiazol-3-yl}-4-aza-tricyclo[2.2.1.0*2,6*]heptane | CHEMBL294082

Type

Small organic molecule

Emp. Form.

C17H14FN3OS

Mol. Mass.

327.376

SMILES

n/a

Structure