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TargetCoagulation factor X
LigandBDBM50080498
Substrate/Competitorn/a
Meas. Tech.ChEMBL_49301
Ki 19±n/a nM
Citation Ewing WRBecker MRManetta VEDavis RSPauls HWMason HChoi-Sledeski YMGreen DCha DSpada APCheney DLMason JSMaignan SGuilloteau JPBrown KColussi DBentley RBostwick JKasiewski CJMorgan SRLeadley RJDunwiddie CTPerrone MHChu V Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem 42:3557-71 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50080498
n/a
NameBDBM50080498
Synonyms:3-{(S)-3-[(7-Methoxy-naphthalene-2-sulfonyl)-thiophen-3-ylmethyl-amino]-2-oxo-pyrrolidin-1-ylmethyl}-benzamidine | CHEMBL119456
TypeSmall organic molecule
Emp. Form.C28H28N4O4S2
Mol. Mass.548.676
SMILESCOc1ccc2ccc(cc2c1)S(=O)(=O)N(Cc1ccsc1)[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O
Structure
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