Reaction Details |
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Target | Vitamin K-dependent protein C |
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Ligand | BDBM13280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_27854 (CHEMBL642279) |
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Ki | 1200±n/a nM |
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Citation | Ewing, WR; Becker, MR; Manetta, VE; Davis, RS; Pauls, HW; Mason, H; Choi-Sledeski, YM; Green, D; Cha, D; Spada, AP; Cheney, DL; Mason, JS; Maignan, S; Guilloteau, JP; Brown, K; Colussi, D; Bentley, R; Bostwick, J; Kasiewski, CJ; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem42:3557-71 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin K-dependent protein C |
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Name: | Vitamin K-dependent protein C |
Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
Type: | Enzyme |
Mol. Mass.: | 52067.73 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 461 |
Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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BDBM13280 |
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n/a |
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Name | BDBM13280 |
Synonyms: | 3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide | CHEMBL327600 | Sulfonamidopyrrolidinone 3a |
Type | Small organic molecule |
Emp. Form. | C23H24N4O4S |
Mol. Mass. | 452.526 |
SMILES | COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O |r| |
Structure |
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