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TargetVitamin K-dependent protein C
LigandBDBM13280
Substrate/Competitorn/a
Meas. Tech.ChEMBL_27854 (CHEMBL642279)
Ki 1200±n/a nM
Citation Ewing, WRBecker, MRManetta, VEDavis, RSPauls, HWMason, HChoi-Sledeski, YMGreen, DCha, DSpada, APCheney, DLMason, JSMaignan, SGuilloteau, JPBrown, KColussi, DBentley, RBostwick, JKasiewski, CJMorgan, SRLeadley, RJDunwiddie, CTPerrone, MHChu, V Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem42:3557-71 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vitamin K-dependent protein C
Name:Vitamin K-dependent protein C
Synonyms:Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor
Type:Enzyme
Mol. Mass.:52067.73
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM13280
n/a
NameBDBM13280
Synonyms:3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide | CHEMBL327600 | Sulfonamidopyrrolidinone 3a
TypeSmall organic molecule
Emp. Form.C23H24N4O4S
Mol. Mass.452.526
SMILESCOc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O |r|
Structure
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