Reaction Details |
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Target | Alpha-1A adrenergic receptor |
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Ligand | BDBM50082790 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_33596 (CHEMBL652805) |
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Ki | 1.9±n/a nM |
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Citation | Nagarathnam, D; Miao, SW; Lagu, B; Chiu, G; Fang, J; Murali Dhar, TG; Zhang, J; Tyagarajan, S; Marzabadi, MR; Zhang, F; Wong, WC; Sun, W; Tian, D; Wetzel, JM; Forray, C; Chang, RS; Broten, TP; Ransom, RW; Schorn, TW; Chen, TB; O'Malley, S; Kling, P; Schneck, K; Bendesky, R; Harrell, CM Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones. J Med Chem42:4764-77 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1A adrenergic receptor |
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Name: | Alpha-1A adrenergic receptor |
Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
Type: | Cell-surface receptors |
Mol. Mass.: | 51511.67 |
Organism: | Homo sapiens (Human) |
Description: | P35348 |
Residue: | 466 |
Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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BDBM50082790 |
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n/a |
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Name | BDBM50082790 |
Synonyms: | 1-(3-{[5-Carbamoyl-4-ethyl-6-(4-nitro-phenyl)-2-oxo-3,6-dihydro-2H-pyrimidine-1-carbonyl]-amino}-propyl)-4-phenyl-piperidine-4-carboxylic acid methyl ester | CHEMBL358595 |
Type | Small organic molecule |
Emp. Form. | C30H36N6O7 |
Mol. Mass. | 592.6428 |
SMILES | CCC1=C(C(N(C(=O)NCCCN2CCC(CC2)(C(=O)OC)c2ccccc2)C(=O)N1)c1ccc(cc1)[N+]([O-])=O)C(N)=O |t:2| |
Structure |
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