| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1D adrenergic receptor |
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| Ligand | BDBM50082870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_32430 (CHEMBL646092) |
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| Ki | 220±n/a nM |
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| Citation |  Wong, WC; Sun, W; Lagu, B; Tian, D; Marzabadi, MR; Zhang, F; Nagarathnam, D; Miao, SW; Wetzel, JM; Peng, J; Forray, C; Chang, RS; Chen, TB; Ransom, R; O'Malley, S; Broten, TP; Kling, P; Vyas, KP; Zhang, K; Gluchowski, C Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series. J Med Chem42:4804-13 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1D adrenergic receptor |
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| Name: | Alpha-1D adrenergic receptor |
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| Synonyms: | ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 60485.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | adrenergic Alpha1D ADRA1D HUMAN::P25100 |
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| Residue: | 572 |
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| Sequence: | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
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| BDBM50082870 |
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| n/a |
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| Name | BDBM50082870 |
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| Synonyms: | 6-(3,4-Difluoro-phenyl)-2,4-dimethyl-1-[5-(4-phenyl-piperidin-1-yl)-pentyl]-1,6-dihydro-pyrimidine-5-carboxylic acid methyl ester | CHEMBL359421 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37F2N3O2 |
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| Mol. Mass. | 509.6305 |
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| SMILES | COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(CC2)c2ccccc2)C1c1ccc(F)c(F)c1 |c:4,t:7| |
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| Structure | 
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