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TargetAlpha-1A adrenergic receptor
LigandBDBM50082869
Substrate/Competitorn/a
Meas. Tech.ChEMBL_33605 (CHEMBL876765)
Ki 4.2±n/a nM
Citation Wong, WCSun, WLagu, BTian, DMarzabadi, MRZhang, FNagarathnam, DMiao, SWWetzel, JMPeng, JForray, CChang, RSChen, TBRansom, RO'Malley, SBroten, TPKling, PVyas, KPZhang, KGluchowski, C Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series. J Med Chem42:4804-13 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Alpha-1A adrenergic receptor
Name:Alpha-1A adrenergic receptor
Synonyms:ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:Cell-surface receptors
Mol. Mass.:51511.67
Organism:Homo sapiens (Human)
Description:P35348
Residue:466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50082869
n/a
NameBDBM50082869
Synonyms:1-{5-[5-Carbamoyl-6-(2,4-difluoro-phenyl)-2,4-dimethyl-6H-pyrimidin-1-yl]-pentyl}-4-phenyl-piperidine-4-carboxylic acid methyl ester | CHEMBL145353
TypeSmall organic molecule
Emp. Form.C31H38F2N4O3
Mol. Mass.552.6552
SMILESCOC(=O)C1(CCN(CCCCCN2C(C(C(N)=O)=C(C)N=C2C)c2ccc(F)cc2F)CC1)c1ccccc1 |c:21,t:18|
Structure
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