| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM50073488 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_139113 (CHEMBL749237) |
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| IC50 | 146±n/a nM |
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| Citation |  Augelli-Szafran, CE; Blankley, CJ; Jaen, JC; Moreland, DW; Nelson, CB; Penvose-Yi, JR; Schwarz, RD; Thomas, AJ Identification and characterization of m1 selective muscarinic receptor antagonists1. J Med Chem42:356-63 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 53079.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
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| Residue: | 479 |
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| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM50073488 |
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| n/a |
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| Name | BDBM50073488 |
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| Synonyms: | 1-Ethyl-4-phenyl-1,2,3,6-tetrahydro-pyridine-3-carboxylic acid benzyl ester; hydrochloride | CHEMBL541584 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23NO2 |
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| Mol. Mass. | 321.4128 |
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| SMILES | CCN1CC=C(C(C1)C(=O)OCc1ccccc1)c1ccccc1 |c:4| |
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| Structure | 
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