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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50076416 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3232 (CHEMBL618918) | ||
| Ki | 0.60±n/a nM | ||
| Citation |  Cappelli, A; Anzini, M; Vomero, S; Canullo, L; Mennuni, L; Makovec, F; Doucet, E; Hamon, M; Menziani, MC; De Benedetti, PG; Bruni, G; Romeo, MR; Giorgi, G; Donati, A Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. J Med Chem42:1556-75 (1999) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50076416 | |||
| n/a | |||
| Name | BDBM50076416 | ||
| Synonyms: | 2-[4-(2-Fluoro-phenyl)-2-(4-methyl-piperazin-1-yl)-quinolin-3-yl]-ethanol | CHEMBL41841 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24FN3O | ||
| Mol. Mass. | 365.4439 | ||
| SMILES | CN1CCN(CC1)c1nc2ccccc2c(c1CCO)-c1ccccc1F |(19.39,-9.64,;18.06,-8.87,;18.06,-7.32,;16.71,-6.51,;15.38,-7.32,;15.38,-8.87,;16.72,-9.64,;14.04,-6.56,;12.7,-7.35,;11.36,-6.56,;10.01,-7.35,;8.68,-6.58,;8.68,-5.02,;10.01,-4.25,;11.36,-5.02,;12.69,-4.24,;14.02,-5,;15.35,-4.23,;16.7,-4.98,;18.03,-4.21,;12.67,-2.71,;14,-1.94,;14,-.4,;12.66,.37,;11.32,-.43,;11.34,-1.96,;10.01,-2.75,)| | ||
| Structure | 
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