| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase HRas |
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| Ligand | BDBM50089967 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_82664 (CHEMBL694129) |
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| IC50 | 15±n/a nM |
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| Citation |  Baraldi, PG; Romagnoli, R; Beria, I; Cozzi, P; Geroni, C; Mongelli, N; Bianchi, N; Mischiati, C; Gambari, R Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A. J Med Chem43:2675-84 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase HRas |
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| Name: | GTPase HRas |
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| Synonyms: | GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 21293.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01112 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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|
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| BDBM50089967 |
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| n/a |
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| Name | BDBM50089967 |
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| Synonyms: | 5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H-indole-2-carboxylic acid (5-{5-[5-(2-carbamimidoyl-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-pyrrol-3-ylcarbamoyl}-1-methyl-1H-pyrrol-3-yl)-amide; hydrochloride | CHEMBL554353 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H44Cl2N12O5 |
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| Mol. Mass. | 855.771 |
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| SMILES | Cn1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4cc5cc(NC(=O)c6ccc(cc6)N(CCCl)CCCl)ccc5[nH]4)cn3C)cn2C)cc1C(=O)NCCC(N)=N |
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| Structure | 
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