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TargetGag-Pol polyprotein [489-587]
LigandBDBM50091601
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159325 (CHEMBL769378)
IC50 1.7±n/a nM
Citation Dorsey, BDMcDonough, CMcDaniel, SLLevin, RBNewton, CLHoffman, JMDarke, PLZugay-Murphy, JAEmini, EASchleif, WAOlsen, DBStahlhut, MWRutkowski, CAKuo, LCLin, JHChen, IWMichelson, SRHolloway, MKHuff, JRVacca, JP Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem43:3386-99 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gag-Pol polyprotein [489-587]
Name:Gag-Pol polyprotein [489-587]
Synonyms:Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:P04585[489-587]
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50091601
n/a
NameBDBM50091601
Synonyms:1-[2-Hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-4-(1H-indol-3-ylmethyl)-piperazine-2-carboxylic acid tert-butylamide | CHEMBL325395
TypeSmall organic molecule
Emp. Form.C39H49N5O4
Mol. Mass.651.8375
SMILESCC(C)(C)NC(=O)C1CN(Cc2c[nH]c3ccccc23)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1C(O)Cc2ccccc12
Structure
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