Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50091609 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_159325 (CHEMBL769378) |
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IC50 | 0.32±n/a nM |
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Citation | Dorsey, BD; McDonough, C; McDaniel, SL; Levin, RB; Newton, CL; Hoffman, JM; Darke, PL; Zugay-Murphy, JA; Emini, EA; Schleif, WA; Olsen, DB; Stahlhut, MW; Rutkowski, CA; Kuo, LC; Lin, JH; Chen, IW; Michelson, SR; Holloway, MK; Huff, JR; Vacca, JP Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem43:3386-99 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50091609 |
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n/a |
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Name | BDBM50091609 |
Synonyms: | 4-Furo[2,3-b]pyridin-2-ylmethyl-1-[2-hydroxy-4-(2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-piperazine-2-carboxylic acid tert-butylamide | CHEMBL324516 |
Type | Small organic molecule |
Emp. Form. | C38H47N5O5 |
Mol. Mass. | 653.8103 |
SMILES | CC(C)(C)NC(=O)C1CN(Cc2cc3cccnc3o2)CCN1CC(O)CC(Cc1ccccc1)C(=O)NC1C(O)Cc2ccccc12 |
Structure |
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