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TargetHuman immunodeficiency virus type 1 protease
LigandBDBM50408998
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159325
IC50 0.18±n/a nM
Citation Dorsey BDMcDonough CMcDaniel SLLevin RBNewton CLHoffman JMDarke PLZugay-Murphy JAEmini EASchleif WAOlsen DBStahlhut MWRutkowski CAKuo LCLin JHChen IWMichelson SRHolloway MKHuff JRVacca JP Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem 43:3386-99 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
BDBM50408998
n/a
NameBDBM50408998
Synonyms:CHEMBL1233940 | L-756423
TypeSmall organic molecule
Emp. Form.C39H48N4O5
Mol. Mass.652.8222
SMILESCC(C)(C)NC(=O)[C@@H]1CN(Cc2cc3ccccc3o2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Structure
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