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TargetNeuraminidase A
LigandBDBM5024
Substrate/Competitorn/a
Meas. Tech.ChEMBL_144590
IC50 1.4±n/a nM
Citation Babu YSChand PBantia SKotian PDehghani AEl-Kattan YLin THHutchison TLElliott AJParker CDAnanth SLHorn LLLaver GWMontgomery JA BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem 43:3482-6 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neuraminidase A
Name:Neuraminidase
Synonyms:Influenza A Virus Neuraminidase | Neuraminidase
Type:Enzyme
Mol. Mass.:50124.14
Organism:Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1))
Description:P03468
Residue:454
Sequence:
MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
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  Blast E-value cutoff:
BDBM5024
n/a
NameBDBM5024
Synonyms:(-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-{[amino(imino)methyl]amino}-2-hydroxycyclopentanecarboxylic Acid | (1S,2S,3R,4R)-4-carbamimidamido-3-[(1S)-1-acetamido-2-ethylbutyl]-2-hydroxycyclopentane-1-carboxylic acid | BCX-1812
TypeSmall organic molecule
Emp. Form.C15H28N4O4
Mol. Mass.328.4072
SMILES[H][C@](NC(C)=O)(C(CC)CC)[C@@H]1[C@H](O)[C@H](C[C@H]1N=C(N)N)C(O)=O |r|
Structure
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