Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50092154

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_48262 (CHEMBL662290)

IC50

259±n/a nM

Citation

Low, CM; Black, JW; Broughton, HB; Buck, IM; Davies, JM; Dunstone, DJ; Hull, RA; Kalindjian, SB; McDonald, IM; Pether, MJ; Shankley, NP; Steel, KI Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists. J Med Chem43:3505-17 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49196.59

Organism:

MOUSE

Description:

Cholecystokinin A CCKBR MOUSE::P56481

Residue:

453

Sequence:

MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50092154

n/a

Name

BDBM50092154

Synonyms:

3-[2-(2-Adamantan-2-yl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-4-phenyl-butyric acid(PD 140458) | CHEMBL420320 | PD-140458

Type

Small organic molecule

Emp. Form.

C34H41N3O4

Mol. Mass.

555.707

SMILES

C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(O)=O)Cc1ccccc1 |wU:1.0,wD:1.13,29.33,TLB:15:16:23:19.25.20,18:19:17.16.22:23,THB:18:17:23:19.25.20,20:19:16:21.22.23,20:21:16:19.18.25,(8.71,-2.48,;8.72,-4.02,;8.72,-5.57,;7.62,-6.66,;8.65,-7.83,;7.85,-9.15,;6.36,-8.79,;5.1,-9.68,;3.71,-9.02,;3.58,-7.48,;4.84,-6.61,;6.22,-7.26,;7.39,-3.25,;6.06,-4.02,;6.06,-5.57,;4.72,-3.25,;3.39,-4.02,;1.99,-3.44,;.64,-3.93,;.64,-5.42,;-.55,-6.69,;.94,-6.27,;.94,-4.68,;2.36,-6.83,;3.37,-5.56,;1.97,-5.91,;10.05,-3.25,;10.05,-1.71,;11.4,-4.02,;12.73,-3.25,;14.06,-4.02,;14.06,-5.57,;15.4,-6.34,;12.73,-6.34,;12.73,-1.71,;14.06,-.94,;15.4,-1.71,;16.73,-.94,;16.73,.6,;15.39,1.37,;14.06,.58,)|

Structure