| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50092849 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_86763 (CHEMBL698663) |
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| Ki | 17±n/a nM |
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| Citation |  Stark, H; Sadek, B; Krause, M; Hüls, A; Ligneau, X; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. J Med Chem43:3987-94 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50092849 |
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| n/a |
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| Name | BDBM50092849 |
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| Synonyms: | 1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-2-trifluoromethyl-phenyl}-ethanone; oxalic acid(0.5M H2O) | CHEMBL131531 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15F3N2O2 |
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| Mol. Mass. | 312.287 |
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| SMILES | CC(=O)c1ccc(OCCCc2cnc[nH]2)cc1C(F)(F)F |
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| Structure | 
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