| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM50092861 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_86763 (CHEMBL698663) |
|---|
| Ki | 325±n/a nM |
|---|
| Citation |  Stark, H; Sadek, B; Krause, M; Hüls, A; Ligneau, X; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. J Med Chem43:3987-94 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48607.98 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
|
|
|
|---|
| BDBM50092861 |
|---|
| n/a |
|---|
| Name | BDBM50092861 |
|---|
| Synonyms: | 1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-2-methoxy-phenyl}-ethanone; compound with but-2-enedioic acid(0.5M H2O) | CHEMBL442762 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18N2O3 |
|---|
| Mol. Mass. | 274.315 |
|---|
| SMILES | COc1cc(OCCCc2cnc[nH]2)ccc1C(C)=O |
|---|
| Structure | 
|
|---|
Search and Browse
