| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
|---|
| Ligand | BDBM50094528 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_157848 (CHEMBL768586) |
|---|
| IC50 | 3.1±n/a nM |
|---|
| Citation |  Portevin, B; Tordjman, C; Pastoureau, P; Bonnet, J; De Nanteuil G, na 1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite. J Med Chem43:4582-93 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 2 |
|---|
| Name: | Prostaglandin G/H synthase 2 |
|---|
| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 69020.39 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | Q05769 |
|---|
| Residue: | 604 |
|---|
| Sequence: | MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
|
|
|
|---|
| BDBM50094528 |
|---|
| n/a |
|---|
| Name | BDBM50094528 |
|---|
| Synonyms: | 5,6-Dimethyl-1,3-diphenyl-4,5,6,7-tetrahydro-2H-isoindole | CHEMBL343339 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N |
|---|
| Mol. Mass. | 301.4247 |
|---|
| SMILES | CC1Cc2c(CC1C)c([nH]c2-c1ccccc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
