| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50072044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_46671 (CHEMBL658630) |
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| IC50 | >10000±n/a nM |
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| Citation |  Leung, D; Abbenante, G; Fairlie, DP Protease inhibitors: current status and future prospects. J Med Chem43:305-41 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50072044 |
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| n/a |
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| Name | BDBM50072044 |
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| Synonyms: | CHEMBL419508 | [(4S,7S,10aS)-4-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-6-oxo-decahydro-pyrido[1,2-a]azepin-7-yl]-carbamic acid benzyl ester | [4-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-6-oxo-decahydro-pyrido[1,2-a]azepin-7-yl]-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N3O7 |
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| Mol. Mass. | 459.4923 |
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| SMILES | OC1OC(=O)C[C@@H]1NC(=O)[C@@H]1CCC[C@@H]2CCC[C@H](NC(=O)OCc3ccccc3)C(=O)N12 |
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| Structure | 
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