| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50084618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196433 (CHEMBL878013) |
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| IC50 | 7.1±n/a nM |
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| Citation |  Leung, D; Abbenante, G; Fairlie, DP Protease inhibitors: current status and future prospects. J Med Chem43:305-41 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50084618 |
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| n/a |
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| Name | BDBM50084618 |
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| Synonyms: | 5-{2-[3-Benzyl-4-(4-methyl-piperazine-1-carbonyl)-2-oxo-piperazin-1-yl]-hexanoylamino}-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid propylamide(pepstatin(A-70450)) | A-70450 | CHEMBL325071 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H68N6O5 |
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| Mol. Mass. | 725.0158 |
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| SMILES | CCCC[C@H](N1CCN([C@H](Cc2ccccc2)C1=O)C(=O)N1CCN(C)CC1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C[C@@H](C(C)C)C(=O)NCCC |
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| Structure | 
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