Reaction Details | |||
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Target | Neprilysin | ||
Ligand | BDBM50403562 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_64981 (CHEMBL675566) | ||
IC50 | 28±n/a nM | ||
Citation | Leung, D; Abbenante, G; Fairlie, DP Protease inhibitors: current status and future prospects. J Med Chem43:305-41 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Neprilysin | |||
Name: | Neprilysin | ||
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 | ||
Type: | Protein | ||
Mol. Mass.: | 85789.59 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | P07861 | ||
Residue: | 750 | ||
Sequence: |
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BDBM50403562 | |||
n/a | |||
Name | BDBM50403562 | ||
Synonyms: | CHEMBL2062138 | UK-69578 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H41NO7 | ||
Mol. Mass. | 515.6383 | ||
SMILES | COCCOCC(CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(=O)Oc1ccc2CCCc2c1 |wU:19.23,16.16,(-7.72,2.65,;-6.63,1.56,;-5.54,2.65,;-4.45,1.54,;-3.34,2.63,;-2.23,1.53,;-2.23,-.01,;-.89,-.72,;.43,.09,;1.68,.98,;1.19,2.46,;-.35,2.44,;-.82,.98,;1.77,-.64,;1.84,-2.18,;3.09,.18,;4.46,-.55,;5.74,.28,;7.1,-.46,;7.16,-2,;5.85,-2.8,;4.5,-2.08,;8.51,-2.73,;8.56,-4.27,;9.82,-1.9,;-3.55,-.81,;-3.5,-2.35,;-4.9,-.07,;-6.21,-.91,;-7.57,-.17,;-8.88,-.99,;-8.84,-2.54,;-9.94,-3.63,;-9.26,-5.01,;-7.72,-4.79,;-7.46,-3.25,;-6.16,-2.45,)| | ||
Structure |