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TargetNeprilysin
LigandBDBM50403562
Substrate/Competitorn/a
Meas. Tech.ChEMBL_64981 (CHEMBL675566)
IC50 28±n/a nM
Citation Leung, DAbbenante, GFairlie, DP Protease inhibitors: current status and future prospects. J Med Chem43:305-41 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neprilysin
Name:Neprilysin
Synonyms:Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:Protein
Mol. Mass.:85789.59
Organism:Rattus norvegicus (Rat)
Description:P07861
Residue:750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50403562
n/a
NameBDBM50403562
Synonyms:CHEMBL2062138 | UK-69578
TypeSmall organic molecule
Emp. Form.C29H41NO7
Mol. Mass.515.6383
SMILESCOCCOCC(CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(=O)Oc1ccc2CCCc2c1 |wU:19.23,16.16,(-7.72,2.65,;-6.63,1.56,;-5.54,2.65,;-4.45,1.54,;-3.34,2.63,;-2.23,1.53,;-2.23,-.01,;-.89,-.72,;.43,.09,;1.68,.98,;1.19,2.46,;-.35,2.44,;-.82,.98,;1.77,-.64,;1.84,-2.18,;3.09,.18,;4.46,-.55,;5.74,.28,;7.1,-.46,;7.16,-2,;5.85,-2.8,;4.5,-2.08,;8.51,-2.73,;8.56,-4.27,;9.82,-1.9,;-3.55,-.81,;-3.5,-2.35,;-4.9,-.07,;-6.21,-.91,;-7.57,-.17,;-8.88,-.99,;-8.84,-2.54,;-9.94,-3.63,;-9.26,-5.01,;-7.72,-4.79,;-7.46,-3.25,;-6.16,-2.45,)|
Structure
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