Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50084872 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_50978 (CHEMBL663521) | ||
Ki | 1.9±n/a nM | ||
Citation | He, L; Gilligan, PJ; Zaczek, R; Fitzgerald, LW; McElroy, J; Shen, HS; Saye, JA; Kalin, NH; Shelton, S; Christ, D; Trainor, G; Hartig, P 4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist. J Med Chem43:449-56 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50084872 | |||
n/a | |||
Name | BDBM50084872 | ||
Synonyms: | CHEMBL138155 | [8-(2,4-Dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]-(1-methoxymethyl-propyl)-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C18H21Cl2N5O | ||
Mol. Mass. | 394.298 | ||
SMILES | CCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(7.35,1.18,;6.96,-.3,;5.47,-.72,;4.4,.37,;4.78,1.85,;3.67,2.94,;5.1,-2.22,;4.62,-3.67,;3.12,-4.02,;2.66,-5.47,;1.16,-5.82,;3.7,-6.59,;5.2,-6.27,;6.43,-7.17,;7.68,-6.27,;9.14,-6.75,;7.2,-4.79,;5.66,-4.82,;6.43,-8.71,;5.13,-9.48,;5.13,-11.02,;6.43,-11.79,;6.43,-13.33,;7.8,-11.02,;7.8,-9.48,;9.11,-8.71,)| | ||
Structure |