| Reaction Details |
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 | Report a problem with these data |
| Target | Nociceptin receptor |
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| Ligand | BDBM50027473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_146118 (CHEMBL754587) |
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| Ki | 24±n/a nM |
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| Citation |  Röver, S; Adam, G; Cesura, AM; Galley, G; Jenck, F; Monsma, FJ; Wichmann, J; Dautzenberg, FM High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor. J Med Chem43:1329-38 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Nociceptin receptor |
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| Name: | Nociceptin receptor |
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| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40702.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41146 |
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| Residue: | 370 |
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| Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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| BDBM50027473 |
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| n/a |
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| Name | BDBM50027473 |
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| Synonyms: | 3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester | 3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester(Lofentanil) | CHEMBL28198 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N2O3 |
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| Mol. Mass. | 408.5332 |
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| SMILES | CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC |
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| Structure | 
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