| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Spermine synthase |
|---|
| Ligand | BDBM50095449 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_223918 (CHEMBL845254) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Casero, RA; Woster, PM Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem44:1-26 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Spermine synthase |
|---|
| Name: | Spermine synthase |
|---|
| Synonyms: | SMS | SPMSY | SPSY_HUMAN | Spermidine aminopropyltransferase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41254.14 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_223918 |
|---|
| Residue: | 366 |
|---|
| Sequence: | MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP
|
|
|
|---|
| BDBM50095449 |
|---|
| n/a |
|---|
| Name | BDBM50095449 |
|---|
| Synonyms: | 2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexylsulfanylmethyl]-5-(6-amino-purin-9-yl)-tetrahydro-furan-3,4-diol | CHEMBL315995 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H38N8O3S |
|---|
| Mol. Mass. | 482.643 |
|---|
| SMILES | NCCCNCCCCCC(CCN)SC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
