Ki Summary

Reaction Details

Report a problem with these data

Target

S-adenosylmethionine decarboxylase proenzyme

Ligand

BDBM50046201

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_197500 (CHEMBL805134)

>1000±n/a nM

Citation

Casero, RA; Woster, PM Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem44:1-26 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

S-adenosylmethionine decarboxylase proenzyme

Name:

S-adenosylmethionine decarboxylase proenzyme

Synonyms:

Type:

Heterotetramer of two alpha and two beta chains

Mol. Mass.:

38337.21

Organism:

Homo sapiens (Human)

Description:

For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used.

Residue:

334

Sequence:

MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS

BDBM50046201

n/a

Name

BDBM50046201

Synonyms:

(2E)-2-((2E)-2-{[(E)-amino(imino)methyl]hydrazono}-1-methylethylidene)hydrazinecarboximidamide | (2E)-2-((2E)-2-{[(Z)-amino(imino)methyl]hydrazono}-1-methylethylidene)hydrazinecarboximidamide | CHEMBL216913 | Methylglyoxalbis(guanylhydrazone) | Mitoguazone | N''-{2-[(diaminomethylene)hydrazono]-1-methylethylidene}carbonohydrazonic diamide | methylglyoxalbisguanylhydrazone

Type

Small organic molecule

Emp. Form.

C5H12N8

Mol. Mass.

184.2024

SMILES

[#6]-[#6](-[#6]=[#7]-[#7]-[#6](-[#7])=[#7])=[#7]\[#7]=[#6](\[#7])-[#7] |w:3.3,8.8|

Structure