| Reaction Details |
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 | Report a problem with these data |
| Target | Intermediate conductance calcium-activated potassium channel protein 4/Potassium voltage-gated channel subfamily E member 1/Potassium voltage-gated channel subfamily KQT member 1 |
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| Ligand | BDBM50099566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71494 (CHEMBL680747) |
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| IC50 | 9±n/a nM |
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| Citation |  Coghlan, MJ; Carroll, WA; Gopalakrishnan, M Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. J Med Chem44:1627-53 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Intermediate conductance calcium-activated potassium channel protein 4/Potassium voltage-gated channel subfamily E member 1/Potassium voltage-gated channel subfamily KQT member 1 |
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| Name: | Intermediate conductance calcium-activated potassium channel protein 4/Potassium voltage-gated channel subfamily E member 1/Potassium voltage-gated channel subfamily KQT member 1 |
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| Synonyms: | Intermediate conductance calcium-activated potassium channel protein 4/Voltage-gated potassium channel beta subunit Mink/Voltage-gated potassium channel subunit Kv7.1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 71494 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Potassium voltage-gated channel subfamily E member 1 |
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| Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 14676.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456351 |
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| Residue: | 129 |
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| Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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| Component 2 |
| Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Synonyms: | IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47723.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361891 |
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| Residue: | 427 |
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| Sequence: | MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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| Component 3 |
| Name: | Potassium voltage-gated channel subfamily KQT member 1 |
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| Synonyms: | KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74739.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454245 |
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| Residue: | 676 |
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| Sequence: | MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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| BDBM50099566 |
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| n/a |
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| Name | BDBM50099566 |
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| Synonyms: | (2-fluorophenyl)-(4-fluorophenyl)phenylacetamide | 2-(4-Fluoro-phenyl)-2-(2-fluoro-phenyl)-2-phenyl-acetamide | CHEMBL42205 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15F2NO |
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| Mol. Mass. | 323.336 |
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| SMILES | NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F |
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| Structure | 
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