Ki Summary

Reaction Details

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Target

Protein kinase C delta type

Ligand

BDBM50099645

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_153143 (CHEMBL759082)

2.71±n/a nM

Citation

Pak, Y; Enyedy, IJ; Varady, J; Kung, JW; Lorenzo, PS; Blumberg, PM; Wang, S Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis. J Med Chem44:1690-701 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Protein kinase C delta type

Name:

Protein kinase C delta type

Synonyms:

Type:

PROTEIN

Mol. Mass.:

77554.99

Organism:

Mus musculus

Description:

ChEMBL_1351519

Residue:

674

Sequence:

MAPFLRISFNSYELGSLQVEDEASQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKTTFD
AHIYEGRVIQIVLMRAAEDPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMCVQY
FLEDGDCKQSMRSEEEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRSSR
KLDTTESVGIYQGFEKKPEVSGSDILDNNGTYGKIWEGSTRCTLENFTFQKVLGKGSFGK
VLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDH
LFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLD
RDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEML
IGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGNIRIHPF
FKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHG
FSFVNPKFEQFLDI

BDBM50099645

n/a

Name

BDBM50099645

Synonyms:

CHEMBL49689 | Thymeleatoxin

Type

Small organic molecule

Emp. Form.

C36H36O10

Mol. Mass.

628.665

SMILES

C[C@@H]1[C@@H](OC(=O)\C=C\c2ccccc2)[C@@]2(OC3(O[C@@H]2[C@@H]2C4O[C@]4(CO)[C@@H](O)[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]12O3)c1ccccc1)C(C)=C |t:33,TLB:15:16:19:14.2.1|

Structure