| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C alpha type |
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| Ligand | BDBM50087241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153127 (CHEMBL759066) |
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| Ki | 28.6±n/a nM |
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| Citation |  Nacro, K; Sigano, DM; Yan, S; Nicklaus, MC; Pearce, LL; Lewin, NE; Garfield, SH; Blumberg, PM; Marquez, VE An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P). J Med Chem44:1892-904 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C alpha type |
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| Name: | Protein kinase C alpha type |
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| Synonyms: | KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 76842.76 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 672 |
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| Sequence: | MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL
SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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| BDBM50087241 |
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| n/a |
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| Name | BDBM50087241 |
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| Synonyms: | 3-Isopropyl-4-methyl-pentanoic acid (S)-1-hydroxymethyl-2-(3-isopropyl-4-methyl-pentanoyloxy)-ethyl ester | 3-Isopropyl-4-methyl-pentanoic acid 1-hydroxymethyl-2-(3-isopropyl-4-methyl-pentanoyloxy)-ethyl ester | 3-Isopropyl-4-methyl-pentanoic acid 3-hydroxy-2-(3-isopropyl-4-methyl-pentanoyloxy)-propyl ester | CHEMBL289230 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H40O5 |
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| Mol. Mass. | 372.5393 |
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| SMILES | CC(C)C(CC(=O)OC[C@H](CO)OC(=O)CC(C(C)C)C(C)C)C(C)C |
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| Structure | 
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