Reaction Details |
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Target | Matrix metalloproteinase-1 (MMP1) |
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Ligand | BDBM50076995 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106154 |
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Ki | <1±n/a nM |
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Citation | Xue CB; Voss ME; Nelson DJ; Duan JJ; Cherney RJ; Jacobson IC; He X; Roderick J; Chen L; Corbett RL; Wang L; Meyer DT; Kennedy K; DeGradodagger WF; Hardman KD; Teleha CA; Jaffee BD; Liu RQ; Copeland RA; Covington MB; Christ DD; Trzaskos JM; Newton RC; Magolda RL; Wexler RR; Decicco CP Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem 44:2636-60 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Matrix metalloproteinase-1 (MMP1) |
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Name: | Matrix metalloproteinase (1 and 13) |
Synonyms: | Fibroblast collagenase | Interstitial collagenase | MMP1 | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50076995 |
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n/a |
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Name | BDBM50076995 |
Synonyms: | (6S,9R,10S)-10-Hydroxycarbamoyl-9-isobutyl-6-methylcarbamoyl-8-oxo-1,7diaza-cyclotridecane-1-carboxylic acid tert-butyl ester | 10-Hydroxycarbamoyl-9-isobutyl-6-methylcarbamoyl-8-oxo-1,7diaza-cyclotridecane-1-carboxylic acid tert-butyl ester | CHEMBL23725 |
Type | Small organic molecule |
Emp. Form. | C23H42N4O6 |
Mol. Mass. | 470.6028 |
SMILES | CNC(=O)[C@@H]1CCCCN(CCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)C(=O)OC(C)(C)C |
Structure |
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