Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50105053 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_65793 (CHEMBL677974) |
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IC50 | >10±n/a nM |
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Citation | Morimoto, H; Ohashi, N; Shimadzu, H; Kushiyama, E; Kawanishi, H; Hosaka, T; Kawase, Y; Yasuda, K; Kikkawa, K; Yamauchi-Kohno, R; Yamada, K Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. J Med Chem44:3369-77 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
Type: | PROTEIN |
Mol. Mass.: | 48707.29 |
Organism: | Sus scrofa |
Description: | ChEMBL_65803 |
Residue: | 427 |
Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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BDBM50105053 |
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n/a |
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Name | BDBM50105053 |
Synonyms: | 4-{4-(4-tert-Butyl-benzenesulfonylamino)-6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-5-yl}-benzoic acid. H2O | CHEMBL115871 |
Type | Small organic molecule |
Emp. Form. | C28H29N5O6S2 |
Mol. Mass. | 595.69 |
SMILES | CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)c2-c2ccc(cc2)C(O)=O)nc1 |
Structure |
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