| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Delta-type opioid receptor |
|---|
| Ligand | BDBM50105100 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_145324 (CHEMBL750412) |
|---|
| IC50 | 7130±n/a nM |
|---|
| Citation |  Poulain, R; Horvath, D; Bonnet, B; Eckhoff, C; Chapelain, B; Bodinier, MC; Déprez, B From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. J Med Chem44:3378-90 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Delta-type opioid receptor |
|---|
| Name: | Delta-type opioid receptor |
|---|
| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 40382.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
|---|
| Residue: | 372 |
|---|
| Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
|
|
|
|---|
| BDBM50105100 |
|---|
| n/a |
|---|
| Name | BDBM50105100 |
|---|
| Synonyms: | 4-[5-(2,4-Dichloro-phenyl)-2H-pyrazol-3-yl]-piperidine-1-carboxylic acid [2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl]-amide | CHEMBL419214 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23Cl2N7O3 |
|---|
| Mol. Mass. | 492.358 |
|---|
| SMILES | Cc1ncc(n1CCNC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
