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TargetKappa-type opioid receptor
LigandBDBM50105085
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145105 (CHEMBL751989)
IC50 83±n/a nM
Citation Poulain, R; Horvath, D; Bonnet, B; Eckhoff, C; Chapelain, B; Bodinier, MC; Déprez, B From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. J Med Chem44:3378-90 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42648.76
Organism:Homo sapiens (Human)
Description:P41145
Residue:380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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  Blast E-value cutoff:
BDBM50105085
n/a
NameBDBM50105085
Synonyms:17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol | CHEMBL895 | N-cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol | NALBUPHINE | US10231963, Table B.1 | US10512644, Compound Nalbuphine | US11534436, Compound Table B.1 | US9233167, Nalbuphine | US9656961, Example 00118 | USRE49340, Rank 9
TypeSmall organic molecule
Emp. Form.C21H27NO4
Mol. Mass.357.4434
SMILESO[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CCC1)c45 |r|
Structure
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