| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50105110 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_84419 (CHEMBL691451) |
|---|
| IC50 | 280±n/a nM |
|---|
| Citation |  Poulain, R; Horvath, D; Bonnet, B; Eckhoff, C; Chapelain, B; Bodinier, MC; Déprez, B From hit to lead. Analyzing structure-profile relationships. J Med Chem44:3391-401 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55808.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
|---|
| Residue: | 487 |
|---|
| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
|
|
|
|---|
| BDBM50105110 |
|---|
| n/a |
|---|
| Name | BDBM50105110 |
|---|
| Synonyms: | 4-(3-Phenyl-propyl)-piperazine-1-carboxylic acid 2-(4-cyano-phenyl)-ethyl ester | CHEMBL325258 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N3O2 |
|---|
| Mol. Mass. | 377.4794 |
|---|
| SMILES | O=C(OCCc1ccc(cc1)C#N)N1CCN(CCCc2ccccc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
