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TargetKappa-type opioid receptor
LigandBDBM50105088
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145103
IC50 104±n/a nM
Citation Poulain RHorvath DBonnet BEckhoff CChapelain BBodinier MCDéprez B From hit to lead. Analyzing structure-profile relationships. J Med Chem 44:3391-401 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | kappa opioid receptor (KOR)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42648.76
Organism:Homo sapiens (Human)
Description:P41145
Residue:380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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  Blast E-value cutoff:
BDBM50105088
n/a
NameBDBM50105088
Synonyms:1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one | 8-Benzo[1,2,5]thiadiazol-5-ylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | CHEMBL325750
TypeSmall organic molecule
Emp. Form.C20H21N5OS
Mol. Mass.379.479
SMILESO=C1NCN(c2ccccc2)C11CCN(Cc2ccc3nsnc3c2)CC1
Structure
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