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TargetReverse transcriptase/RNaseH
LigandBDBM50102270
Substrate/Competitorn/a
Meas. Tech.ChEMBL_196191 (CHEMBL803636)
Ki 40±n/a nM
Citation Campiani, GAiello, FFabbrini, MMorelli, ERamunno, AArmaroli, SNacci, VGarofalo, AGreco, GNovellino, EMaga, GSpadari, SBergamini, AVentura, LBongiovanni, BCapozzi, MBolacchi, FMarini, SColetta, MGuiso, GCaccia, S Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. J Med Chem44:305-15 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase/RNaseH
Name:Reverse transcriptase/RNaseH
Synonyms:HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:PROTEIN
Mol. Mass.:65229.15
Organism:Human immunodeficiency virus 1
Description:ChEMBL_1473730
Residue:566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50102270
n/a
NameBDBM50102270
Synonyms:1-(5-Bromo-pyridin-2-yl)-3-[2-(9-fluoro-4-oxo-4H-pyrrolo[1,2-a]quinoxalin-5-yl)-ethyl]-thiourea | CHEMBL107099
TypeSmall organic molecule
Emp. Form.C19H15BrFN5OS
Mol. Mass.460.323
SMILESFc1cccc2n(CCNC(=S)Nc3ccc(Br)cn3)c(=O)c3cccn3c12
Structure
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