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TargetLeukocyte elastase
LigandBDBM50098815
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63965
Ki 12±n/a nM
Citation Ohmoto KYamamoto TOkuma MHoriuchi TImanishi HOdagaki YKawabata KSekioka THirota YMatsuoka SNakai HToda MCheronis JCSpruce LWGyorkos AWieczorek M Development of orally active nonpeptidic inhibitors of human neutrophil elastase. J Med Chem 44:1268-85 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50098815
n/a
NameBDBM50098815
Synonyms:1-(2-Methanesulfonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid [1-(5-tert-butyl-[1,3,4]oxadiazole-2-carbonyl)-2-methyl-propyl]-amide | CHEMBL281912
TypeSmall organic molecule
Emp. Form.C22H37N5O6S
Mol. Mass.499.624
SMILESCC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NS(C)(=O)=O)C(C)C)C(=O)c1nnc(o1)C(C)(C)C
Structure
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