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TargetNeutrophil elastase
LigandBDBM50098823
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63965 (CHEMBL677434)
Ki 6.76±n/a nM
Citation Ohmoto, KYamamoto, TOkuma, MHoriuchi, TImanishi, HOdagaki, YKawabata, KSekioka, THirota, YMatsuoka, SNakai, HToda, MCheronis, JCSpruce, LWGyorkos, AWieczorek, M Development of orally active nonpeptidic inhibitors of human neutrophil elastase. J Med Chem44:1268-85 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50098823
n/a
NameBDBM50098823
Synonyms:2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-[1-(5-butyl-[1,3,4]oxadiazole-2-carbonyl)-2-methyl-propyl]-acetamide | CHEMBL22757
TypeSmall organic molecule
Emp. Form.C23H27FN6O4
Mol. Mass.470.4967
SMILESCCCCc1nnc(o1)C(=O)[C@@H](NC(=O)Cn1c(ncc(N)c1=O)-c1ccc(F)cc1)C(C)C
Structure
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