Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50098829 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63965 (CHEMBL677434) |
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Ki | 836±n/a nM |
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Citation | Ohmoto, K; Yamamoto, T; Okuma, M; Horiuchi, T; Imanishi, H; Odagaki, Y; Kawabata, K; Sekioka, T; Hirota, Y; Matsuoka, S; Nakai, H; Toda, M; Cheronis, JC; Spruce, LW; Gyorkos, A; Wieczorek, M Development of orally active nonpeptidic inhibitors of human neutrophil elastase. J Med Chem44:1268-85 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50098829 |
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n/a |
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Name | BDBM50098829 |
Synonyms: | CHEMBL23643 | N-[1-(5-tert-Butyl-[1,3,4]oxadiazole-2-carbonyl)-2-methyl-propyl]-2-(4-isopropyl-2,5-dioxo-imidazolidin-1-yl)-acetamide |
Type | Small organic molecule |
Emp. Form. | C19H29N5O5 |
Mol. Mass. | 407.4641 |
SMILES | CC(C)[C@H](NC(=O)Cn1c(O)c([nH]c1=O)C(C)C)C(=O)c1nnc(o1)C(C)(C)C |
Structure |
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