| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50098847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197665 (CHEMBL807474) |
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| Ki | 103±n/a nM |
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| Citation |  Akahoshi, F; Ashimori, A; Sakashita, H; Yoshimura, T; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase. J Med Chem44:1286-96 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | CMA1_RAT | Cma1 | Mast cell protease 3 | Mcpt3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27587.00 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_197666 |
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| Residue: | 247 |
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| Sequence: | MNLHALCLLLLLLGSSTKAGEIIGGTECIPHSRPYMAYLEIVTSDNYLSACSGFLIRRNF
VLTAAHCAGRSITVLLGAHNKTYKEDTWQKLEVEKQFIHPNYDKRLVLHDIMLLKLKEKA
KLTLGVGTLPLSANFNFIPPGRMCRAVGWGRTNVNEPASDTLQEVKMRLQEPQSCKHFTS
FQHKSQLCVGNPKKMQNVYKGDSGGPLLCAGIAQGIASYVHPNAKPPAVFTRISHYRPWI
NKILREN
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| BDBM50098847 |
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| n/a |
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| Name | BDBM50098847 |
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| Synonyms: | 2-(2-{2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-3-phenyl-propionyl)-benzooxazole-5-carboxylic acid methyl ester | CHEMBL281124 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H24FN5O6 |
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| Mol. Mass. | 569.5399 |
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| SMILES | COC(=O)c1ccc2oc(nc2c1)C(=O)C(Cc1ccccc1)NC(=O)Cn1c(ncc(N)c1=O)-c1ccc(F)cc1 |
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| Structure | 
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