| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50098874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_217039 (CHEMBL821573) |
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| Ki | 28±n/a nM |
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| Citation |  Akahoshi, F; Ashimori, A; Sakashita, H; Yoshimura, T; Eda, M; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase. J Med Chem44:1297-304 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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| BDBM50098874 |
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| n/a |
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| Name | BDBM50098874 |
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| Synonyms: | 4-{2-[5-Amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-acetylamino}-2,2-difluoro-3-oxo-5-phenyl-pentanoic acid benzylamide | CHEMBL24734 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26ClF2N5O4 |
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| Mol. Mass. | 594.008 |
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| SMILES | Nc1cnc(-c2cccc(Cl)c2)n(CC(=O)NC(Cc2ccccc2)C(=O)C(F)(F)C(=O)NCc2ccccc2)c1=O |
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| Structure | 
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