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TargetInosine-5'-monophosphate dehydrogenase 2
LigandBDBM50113215
Substrate/Competitorn/a
Meas. Tech.ChEMBL_89812 (CHEMBL697550)
IC50 13±n/a nM
Citation Dhar, TGShen, ZGuo, JLiu, CWatterson, SHGu, HHPitts, WJFleener, CARouleau, KASherbina, NZMcIntyre, KWShuster, DJWitmer, MRTredup, JAChen, BCZhao, RBednarz, MSCheney, DLMacMaster, JFMiller, LMBerry, KKHarper, TWBarrish, JCHollenbaugh, DLIwanowicz, EJ Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity. J Med Chem45:2127-30 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Inosine-5'-monophosphate dehydrogenase 2
Name:Inosine-5'-monophosphate dehydrogenase 2
Synonyms:IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:Enzyme
Mol. Mass.:55806.87
Organism:Homo sapiens (Human)
Description:Recombinant IMPDH2 expressed in E. coli.
Residue:514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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  Blast E-value cutoff:
BDBM50113215
n/a
NameBDBM50113215
Synonyms:CHEMBL67036 | N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phenylamino)-oxazol-5-yl]-phenyl}-N-methyl-3-morpholin-4-yl-propionamide
TypeSmall organic molecule
Emp. Form.C27H29N5O5
Mol. Mass.503.5497
SMILESCOc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CCN2CCOCC2)ccc1-c1cnco1
Structure
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