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TargetProtein-tyrosine phosphatase 1B
LigandBDBM50113296
Substrate/Competitorn/a
Meas. Tech.ChEMBL_162252
IC50 9000±n/a nM
Citation Doman TNMcGovern SLWitherbee BJKasten TPKurumbail RStallings WCConnolly DTShoichet BK Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. J Med Chem 45:2213-21 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Protein-tyrosine phosphatase 1B
Name:Protein-tyrosine phosphatase 1B
Synonyms:PTP1B | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:Protein phosphatase
Mol. Mass.:49963.76
Organism:Homo sapiens (Human)
Description:Human recombinant GST-fusion PTP1B (1-435).
Residue:435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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  Blast E-value cutoff:
BDBM50113296
n/a
NameBDBM50113296
Synonyms:2-Hydroxy-4-[5-(4-oxo-3-phenyl-2-phenylimino-thiazolidin-5-ylidenemethyl)-furan-2-yl]-benzoic acid anion
TypeSmall organic molecule
Emp. Form.C27H17N2O5S
Mol. Mass.481.5
SMILESOc1cc(ccc1C([O-])=O)-c1ccc(\C=C2\S\C(=N/c3ccccc3)N(C2=O)c2ccccc2)o1
Structure
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