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Target12-Lipoxygenase (12-LOX)
LigandBDBM50114095
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209
IC50 360±n/a nM
Citation Whitman SGezginci MTimmermann BNHolman TR Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem 45:2659-61 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
12-Lipoxygenase (12-LOX)
Name:Arachidonate 12-lipoxygenase
Synonyms:12-LOX | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12
Type:Protein
Mol. Mass.:75689.18
Organism:Homo sapiens (Human)
Description:P18054
Residue:663
Sequence:
MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50114095
n/a
NameBDBM50114095
Synonyms:4-[(2R,3S)-4-(4,5-dihydroxy-2-nitrophenyl)-2,3-dimethylbutyl]-5-nitrobenzene-1,2-diol | CHEMBL92359
TypeSmall organic molecule
Emp. Form.C18H20N2O8
Mol. Mass.392.36
SMILESC[C@@H](Cc1cc(O)c(O)cc1[N+]([O-])=O)[C@H](C)Cc1cc(O)c(O)cc1[N+]([O-])=O
Structure
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