| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50114096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_20 (CHEMBL615134) |
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| IC50 | 160±n/a nM |
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| Citation |  Whitman, S; Gezginci, M; Timmermann, BN; Holman, TR Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem45:2659-61 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
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| Type: | Protein |
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| Mol. Mass.: | 74804.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 662 |
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| Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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| BDBM50114096 |
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| n/a |
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| Name | BDBM50114096 |
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| Synonyms: | 4-ethyl-5-[4-(2-ethyl-4,5-dihydroxyphenyl)-2,3-dimethyl-(2S,3R)-butyl]-1,2-benzenediol | CHEMBL92212 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30O4 |
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| Mol. Mass. | 358.4712 |
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| SMILES | CCc1cc(O)c(O)cc1C[C@H](C)[C@H](C)Cc1cc(O)c(O)cc1CC |
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| Structure | 
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