| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM107681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_88608 (CHEMBL873101) |
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| IC50 | >1000000±n/a nM |
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| Citation |  Pais, GC; Zhang, X; Marchand, C; Neamati, N; Cowansage, K; Svarovskaia, ES; Pathak, VK; Tang, Y; Nicklaus, M; Pommier, Y; Burke, TR Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. J Med Chem45:3184-94 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM107681 |
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| n/a |
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| Name | BDBM107681 |
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| Synonyms: | (2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxobut-2-enoic acid (Compound 2) | CHEMBL19977 | CHEMBL320261 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20O6 |
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| Mol. Mass. | 404.412 |
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| SMILES | OC(=O)C(=O)CC(=O)c1cc(OCc2ccccc2)cc(OCc2ccccc2)c1 |
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| Structure | 
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