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TargetSubstance-K receptor
LigandBDBM50409575
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209010 (CHEMBL813648)
Ki 0.92±n/a nM
Citation Albert, JS; Aharony, D; Andisik, D; Barthlow, H; Bernstein, PR; Bialecki, RA; Dedinas, R; Dembofsky, BT; Hill, D; Kirkland, K; Koether, GM; Kosmider, BJ; Ohnmacht, C; Palmer, W; Potts, W; Rumsey, W; Shen, L; Shenvi, A; Sherwood, S; Warwick, PJ; Russell, K Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity. J Med Chem45:3972-83 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Substance-K receptor
Name:Substance-K receptor
Synonyms:NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:Protein
Mol. Mass.:44455.78
Organism:Homo sapiens (Human)
Description:P21452
Residue:398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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  Blast E-value cutoff:
BDBM50409575
n/a
NameBDBM50409575
Synonyms:CHEMBL339767 | ZD-7944
TypeSmall organic molecule
Emp. Form.C31H34Cl2N2O2S
Mol. Mass.569.585
SMILESCCN1[C@H]([C@@H](CCN2CCC(CC2)c2ccccc2[S@](C)=O)c2ccc(Cl)c(Cl)c2)c2ccccc2C1=O
Structure
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