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TargetSodium-dependent noradrenaline transporter
LigandBDBM50118272
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145004
Ki 0.9±n/a nM
Citation Houlihan WJKelly LPankuch JKoletar JBrand LJanowsky AKopajtic TA Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. J Med Chem 45:4097-109 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Monoamine transporter
Synonyms:NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SLC6A2 | Serotonin Transporter (SERT) | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:Competition binding assay was determined using hNET stably expressed in HEK293 cells.
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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  Blast E-value cutoff:
BDBM50118272
n/a
NameBDBM50118272
Synonyms:5-(4-Chloro-phenyl)-9-fluoro-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol | CHEMBL336100
TypeSmall organic molecule
Emp. Form.C16H12ClFN2O
Mol. Mass.302.731
SMILESOC1(N2CCN=C2c2c1cccc2F)c1ccc(Cl)cc1 |c:5|
Structure
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