| Reaction Details |
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 | Report a problem with these data |
| Target | Serotonin (5-HT) receptor |
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| Ligand | BDBM50108690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2622 |
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| Ki | 0.18±n/a nM |
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| Citation |  Fletcher SR; Burkamp F; Blurton P; Cheng SK; Clarkson R; O'Connor D; Spinks D; Tudge M; van Niel MB; Patel S; Chapman K; Marwood R; Shepheard S; Bentley G; Cook GP; Bristow LJ; Castro JL; Hutson PH; MacLeod AM 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem 45:492-503 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serotonin (5-HT) receptor |
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| Name: | Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a) |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT-S1A | 5-HT-S2 | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2A | Serotonin Receptor 2A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52852.05 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat cortex membranes 5-HT2A receptors. |
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| Residue: | 471 |
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| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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| BDBM50108690 |
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| n/a |
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| Name | BDBM50108690 |
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| Synonyms: | 1-(2,4-difluorophenethyl)-4-(phenylsulfonyl)piperidine | 4-Benzenesulfonyl-1-[2-(2,4-difluoro-phenyl)-ethyl]-piperidine | CHEMBL145939 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21F2NO2S |
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| Mol. Mass. | 365.437 |
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| SMILES | Fc1ccc(CCN2CCC(CC2)S(=O)(=O)c2ccccc2)c(F)c1 |
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| Structure | 
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