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TargetSerotonin (5-HT) receptor
LigandBDBM50108701
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2622
Ki 0.61±n/a nM
Citation Fletcher SRBurkamp FBlurton PCheng SKClarkson RO'Connor DSpinks DTudge Mvan Niel MBPatel SChapman KMarwood RShepheard SBentley GCook GPBristow LJCastro JLHutson PHMacLeod AM 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem 45:492-503 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Serotonin (5-HT) receptor
Name:Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)
Synonyms:5-HT-2 | 5-HT-2A | 5-HT-S1A | 5-HT-S2 | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2A | Serotonin Receptor 2A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52852.05
Organism:Rattus norvegicus (rat)
Description:Rat cortex membranes 5-HT2A receptors.
Residue:471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50108701
n/a
NameBDBM50108701
Synonyms:1'-[2-(2,4-Difluorophenyl)ethyl]-3,4-dihydrospiro[2H-1-benzothiopyran-2,4'-piperidine]-1,1-dioxide | 1-[2-(2,4-difluorophenyl)ethyl]-3',4'-dihydrospiro[piperidine-4,2'-thiochromene] 1',1'-dioxide | CHEMBL146595
TypeSmall organic molecule
Emp. Form.C21H23F2NO2S
Mol. Mass.391.475
SMILESFc1ccc(CCN2CCC3(CC2)CCc2ccccc2S3(=O)=O)c(F)c1
Structure
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