Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase 1 |
---|
Ligand | BDBM50108771 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_124014 (CHEMBL729502) |
---|
IC50 | 2800±n/a nM |
---|
Citation | Tasdemir, D; Mallon, R; Greenstein, M; Feldberg, LR; Kim, SC; Collins, K; Wojciechowicz, D; Mangalindan, GC; Concepción, GP; Harper, MK; Ireland, CM Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem45:529-32 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase 1 |
---|
Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
|
|
|
BDBM50108771 |
---|
n/a |
---|
Name | BDBM50108771 |
Synonyms: | 2'-amino-3'-methoxyflavone | 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one | 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one(PD98059) | 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one | CHEMBL35482 | PD-98059 |
Type | Small organic molecule |
Emp. Form. | C16H13NO3 |
Mol. Mass. | 267.2793 |
SMILES | COc1cccc(c1N)-c1cc(=O)c2ccccc2o1 |
Structure |
|