Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Dual specificity mitogen-activated protein kinase kinase 1 | ||
Ligand | BDBM7491 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_123850 (CHEMBL731425) | ||
IC50 | 2500±n/a nM | ||
Citation | Tasdemir, D; Mallon, R; Greenstein, M; Feldberg, LR; Kim, SC; Collins, K; Wojciechowicz, D; Mangalindan, GC; Concepción, GP; Harper, MK; Ireland, CM Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem45:529-32 (2002) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Dual specificity mitogen-activated protein kinase kinase 1 | |||
Name: | Dual specificity mitogen-activated protein kinase kinase 1 | ||
Synonyms: | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2 | ||
Type: | Other Protein Type | ||
Mol. Mass.: | 43439.03 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates. | ||
Residue: | 393 | ||
Sequence: |
| ||
BDBM7491 | |||
n/a | |||
Name | BDBM7491 | ||
Synonyms: | (4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one | (Z)-4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one | (Z)-hymenialdisine | 2-amino-5-[(4Z)-2-bromo-8-oxo-1H,4H,5H,6H,7H,8H-pyrrolo[2,3-c]azepin-4-ylidene]-4,5-dihydro-1H-imidazol-4-one | 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one | 4-(2-Amino-5-oxo-3,5-dihydro-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one | 4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one | 4-[2-Amino-5-oxo-1,5-dihydro-imidazol-(4Z)-ylidene]-2-bromo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one | 4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4Z)-ylidene]-2-bromo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one | CHEMBL361708 | Hymenialdisine | Hymenialdisine, 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C11H10BrN5O2 | ||
Mol. Mass. | 324.133 | ||
SMILES | NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]c(Br)cc12 |w:7.19,t:1| | ||
Structure |